[vc_row full_width=”stretch_row_content_no_spaces”][vc_column][vc_single_image image=”398″ img_size=”full”][/vc_column][/vc_row][vc_row][vc_column][vc_empty_space height=”80px”][/vc_column][/vc_row][vc_row equal_height=”yes”][vc_column width=”1/2″][vc_single_image image=”747″ img_size=”300×300″ alignment=”center” onclick=”custom_link” link=”https://www.t4ss-conference-nancy.org/wp-content/uploads/2025/02/Conference-guide-T4SS-web.pdf”][vc_empty_space][/vc_column][vc_column width=”1/2″][vc_column_text]Access all the essential information about the congress!

We are pleased to present the Conference Guide for the T4SS Conference!
Find all the key details about the event, including practical information, highlights, the scientific program, and much more ![/vc_column_text][vc_empty_space][vc_btn title=”Download the conference guide” style=”flat” color=”mulled-wine” align=”center” link=”url:https%3A%2F%2Fwww.t4ss-conference-nancy.org%2Fwp-content%2Fuploads%2F2025%2F02%2FConference-guide-T4SS-web.pdf|target:_blank”][/vc_column][/vc_row][vc_row equal_height=”yes”][vc_column width=”1/2″][vc_empty_space][vc_column_text]

Discover the program!

The program is online just here  !

[/vc_column_text][vc_empty_space][vc_btn title=”Download the program” style=”flat” color=”mulled-wine” align=”right” link=”url:https%3A%2F%2Fwww.t4ss-conference-nancy.org%2Fwp-content%2Fuploads%2F2025%2F01%2FProgramme-scientifique-T4SS-2025.pdf|target:_blank”][/vc_column][vc_column width=”1/2″][vc_single_image image=”591″ img_size=”300×300″ alignment=”center” onclick=”custom_link” img_link_target=”_blank” link=”https://www.t4ss-conference-nancy.org/wp-content/uploads/2025/01/Programme-scientifique-T4SS-2025.pdf”][/vc_column][/vc_row][vc_row disable_element=”yes”][vc_column][vc_empty_space][vc_single_image image=”628″ img_size=”full” alignment=”center”][vc_empty_space][/vc_column][/vc_row][vc_row][vc_column][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][tz_title_meetup section_type=”type2″ title=”The program per day” color_title=”#b04746″][/tz_title_meetup][vc_empty_space][vc_tta_tabs style=”modern” shape=”square” spacing=”3″ gap=”2″ active_section=”1″ no_fill_content_area=”true”][vc_tta_section title=”Monday 17th” tab_id=”1729779941404-95841035-8cbf”][vc_column_text]12:00 – 14:30 Registration & poster set-up

     14:30 Opening of the congress

[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]14:45-18:20  Session 1 – T4SS Structure and Function : Structure and dynamics- Assembly mechanisms

| Chair: Elisabeth Grohmann

14:45     Keynote lecture – Gabriel WAKSMAN

 “Progress in the structural and molecular biology of bacterial conjugation in Gram-negative bacteria”

15:30     Robine MAFFO-WOULEFACK
“Elucidating assembly and function of VirB8 cell wall subunits refines the DNA translocation model in Gram-positive Type IV secretion system“

15:50     Kieran DEANE-ALDER
“Uncovering the molecular architecture of a Gram-positive Type IV secretion system“

16:10     Main talk – Melanie OHI
“Structural and functional analysis of the Legionella pneumophila Dot/Icm Type IV secretion system“[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]16:40-17:10   Coffee Break[/vc_column_text][vc_column_text]

17:10     Main Talk – Walter KELLER
“Functional and Structural Characterization of essential and regulatory components of a Gram-positive Type IV secretion system“

17:40     Charline FOCANT
“The VirB type IV secretion system is localized at the growth pole in Brucella abortus“

18:00     Chiamaka OKOYE
“Molecular interactions required for secretion of Helicobacter pylori CagA“[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]18:30   Welcome Cocktail – Campus Lettres et Sciences Humaines[/vc_column_text][/vc_tta_section][vc_tta_section title=”Tuesday 18th” tab_id=”1729779941404-f92a7563-6454″][vc_column_text]8:30-9:00   Welcome participants

9:00-11:15   Session 2 – Host-Pathogen Interactions : Effectors diversity and function

| Chair: Abdelrahim Zoued 

9:00   Keynote lecture – Suzana SALCEDO
“The Ins and Outs of Brucella: deciphering the role of effectors in pathogenesis”

9:45   Monica ROLANDO
“Characterization of a new nucleomodulin of Legionella pneumophila”

10:05  Matteo BONAZZI
“The multifunction Coxiella effector Vice stimulates macropinocytosis and interferes with the ESCRT machinery”

10:25  Gunnar SCHROEDER 
“Disruption of the nucleoli and translation by a Legionella Dot/Icm T4SS effector”

10:45  Main Talk – Steffen BACKERT
“Composition and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system”[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]11:15-12:30   Coffee Break & Poster Session 1[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]12:30-14:00   Lunch[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]14:00-16:30   City Tour[/vc_column_text][vc_empty_space][vc_btn title=”Discover the activities” style=”flat” color=”primary” align=”left” link=”url:https%3A%2F%2Fwww.t4ss-conference-nancy.org%2Fsocial-program%2F|title:Social%20Program|target:_blank”][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]16:30-18:45   Session 3 – T4SS Structure and Function : Conjugative systems – DNA import/export systems

| Chair: Kevin Macé

16:30   Keynote lecture – Peter CHRISTIE
“Structural and Functional Plasticity of the T4SSs Exemplified Through Studies of the F system”

17:15   Shubha UDUPA
“Visualizing the structure and dynamics of the horizontal gene transfer during bacterial conjugation“

17:35  Haifa LAROUSSI
“Exploration of DNA processing mediated by MOBT relaxases during bacterial conjugation”

17:55  Sunada WILLIAMS 
“Cryo-EM structure of the F plasmid relaxosome provides a molecular basis for DNA recruitment and processing in bacterial conjugation”

18:15  Main Talk – Aravindan ILANGOVAN
“Molecular Mechanism For Loading Two Relaxases During Conjugation Initiation”[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]20:00  Diner at the Exclesior (optional)[/vc_column_text][vc_empty_space][vc_btn title=”Discover the menu” style=”flat” color=”primary” align=”left” link=”url:https%3A%2F%2Fwww.t4ss-conference-nancy.org%2Fwp-content%2Fuploads%2F2024%2F07%2FMENU-EXCELSIOR-ENGLISH.pdf|title:Discover%20the%20menu|target:_blank”][/vc_tta_section][vc_tta_section title=”Wednesday 19th” tab_id=”1729780038178-b4f14405-ecb6″][vc_column_text]8:15-8:45   Welcome participants

8:45-11:00 Session 4 – Bioinformatics, Genomics and Evolution : Detection and classification, Diversity and Evolution, Bioinformatic Tools

| Chair: Virginie Libante

8:45  Keynote lecture – Hélène CHIAPELLO and Nathalie LEBLOND-BOURGET

“Unveilling Integrative Conjugative Elements: detection and annotation in Bacillota genomes”

9:30  Toufik HAMADOUCHE
“PO-CBR for delimiting integrated mobile elements transferred by conjugation“

9:50  Sophie PAYOT
“Prevalence and diversity of Integrative and conjugative or mobilizable elements carrying antimicrobial resistance genes in Streptococcus suis“

10:10  Daniel GARCIA-LOPEZ
“Conjugative sabotage: new fertility inhibitors against broad-host-range plasmids“

10:30  Main talk – Charles COLUZZI
“Evolution of plasmid mobility: origin and fate of non-conjugative plasmids“[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]11:00-11:20 Coffee Break[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]11:20-12:30 Session 5 – T4SS Structure and Function : Non-Canonical Systems, Interbacterial Systems

 | Chair: Ronnie Bertsson

11:20  Main talk – Chuck FARAH
“Substrate selection and fratricide avoidance by the bactericidal Type IV secretion system of Xanthomonadaceae“

11:50  Chloé PEDUZZI
“Type IV secretion system drives interbacterial competition in the plant pathogen Xanthomonas“

12:10  Pauline GASCHT
“The non-canonical TraB-dependent Actinomycete ICEs (AICEs) mediate large-scale chromosomal transfer in Streptomyces“[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]12:30-14:00 Lunch[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]14:00-17:20 Session 6 – Host-Pathogen Interactions : Targeting eucaryotic signaling pathways

| Chair: Steffen Backert

14:00  Keynote lecture – Sagar BHOGARAJU
“Effectors of Legionella pneumophila and their interaction with the host ubiquitin system“

14:45  Maren KETTERER
“Revisiting effector functions: involvement of a putative T4SS effector in the envelope integrity of Brucella“

15:05  Christine JOSENHANS
“Exploring novel protein-protein interactions and functions of selected Helicobacter pylori Cag Type 4 secretion system (CagT4SS) outer proteins“[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]15:25-16:30 Coffee Break & Poster Session 2[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]

16:30  Main talk – Christoph DEHIO
“Translocation of YopJ family effector proteins through the VirB/VirD4 T4SS of Bartonella“

17:00  Carmen BUCHRIESER
“Legionella pneumophila: Assessment of effector secretion kinetics in real time in Acanthamoeba“[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]20:00  Diner Gala at the Grands Salons[/vc_column_text][vc_empty_space][vc_btn title=”Discover the Gala’s program” style=”flat” color=”primary” align=”left” link=”url:https%3A%2F%2Fwww.t4ss-conference-nancy.org%2Fsocial-program%2F|title:Social%20Program”][/vc_tta_section][vc_tta_section title=”Thursday 20th” tab_id=”1729780040585-f1d9b8ff-7641″][vc_column_text]8:15-8:45  Welcome partcipants

8:45-10:15 Session 7 – T4SS Structure and Function : T4SS effectors recruitment

| Chair: Christine Josenhans

8:45   Main Talk – Samuel WAGNER
“The T4bSS of Legionella features a two-step secretion pathway with an inner membrane intermediate for secretion of transmembrane effectors“

9:15   Chloé DUGELAY
“Exploring the structure and function of Brucella abortus virulence factor VirJ in T4SS effectors translocation“

9:35   Main talk – Carrie SHAFFER
“Architectural asymmetry enables DNA transport through the Helicobacter pylori cag Type IV secretion system“[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]10:05-10:25  Coffee Break[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]10:25-13:00 Session 8 – Impact of Conjugative Transfer : Dissemination in the environment, Consequence on bacterial fitness, Mobilization

| Chair: Xavier Bellanger

10:25   Keynote lecture – Uli KLÜMPER
“Insights into the T4SS-mediated spread of plasmids and antimicrobial resistance“

11:10   Matxalen LLOSA
“Bacterial conjugation – based tools for manipulating and exploring long-range horizontal gene transfer“

11:30  Laurent TERRADOT
“Structural insights into a ParB-like protein of the F-plasmid that reprograms the gene expression profile of the recipient cell“

11:50  Sarah BIGOT
“Competition between conjugative plasmids by fertility inhibition protein“

12:10  Virginie LIBANTE
“Uncovering the role of IMEs in antimicrobial resistance and horizontal gene transfer“

12:30   Main Talk – Vincent BURRUS
“Entry and surface exclusion of IncC plasmids and SGI1: an asymmetric interplay gene transfer“[/vc_column_text][vc_empty_space][vc_separator color=”mulled_wine”][vc_empty_space][vc_column_text]13:00  Poster & Talk Prices

    Concluding remarks

    Lunch bag (optionnal)

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